Adultbi cam

In adult mammals, many tissues have the capacity to self-renew to maintain healthy function and after damage. In the intestine and stomach, adult stem cell populations are constantly replenishing, while in the liver and pancreas cell proliferation is limited. [Epub ahead of print] • Huch M*, Bonfanti P*, Boj SF*, Sato T*, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E, Vries RG, Heimberg H and Clevers H (2013) Unlimited EMBO J 32(20):2708-21.

Chronic liver disease and pancreatic cancer are strongly associated with inflammation and tissue damage, which activates stem cells and progenitor cells to repair lost tissue. • Huch M*, Dorrell C*, Boj SF, van Es JH, Li VSW, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries R, Grompe M and Clevers H (2013) In vitro expansion of single Lgr5 liver stem cells induced by Wnt-driven regeneration. *, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R and Clevers H (2010) Lgr5( ve) stem cells drive self-renewal in the stomach and build long-lived gastric units The liver is a very slowly dividing organ but, when damaged by toxins present on the food or other environmental agents, it starts the machinery to regenerate itself and bring the organ back to its original resting state.

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